Welcome to the EF-CLIF web-page, the main working tool of our investigators. All protocols of the multicenter prospective observational studies and randomized controlled trials performed by our network of Hospitals and their clinical research forms are loaded in the reserved research area of the webpage. You will find in other areas detailed information related to the organization, rules, steering committees, research facilities and scientific production as well as the past and the future educational activities of the EF CLIF.

TWO LINES OF RESEARCH

EASL CLIF CONSORTIUM

Performs clinical studies to improve the diagnosis and treatment of patients with Chronic Liver Failure (CLIF).

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GRIFOLS CHAIR FOR TRANSLATIONAL
RESEARCH

Promote translational research studies in Chronic Liver Failure (CLIF).

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NEWS&EVENTS

November 13th 2017 NEWS FROM THE GRIFOLS CHAIR #3 Addressing patients' diversity in acutely decompensated cirrhosis Richard Moreau, Joan Clària and Vicente Arroyo

The CANONIC study has shown that among patients with acute decompensation (AD) of cirrhosis, those who had Acute-on-Chronic Liver Failure (ACLF, characterized by intense systemic inflammation, organ failures and poor outcome) were clearly distinct from those with traditional AD (who do not have organ failures and have good outcome).

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May 26th 2017 EASL Clif Consortium meetings at the EASL Annual Congress 2017 As we did in previous years, during the last EASL Congress (Amsterdam, April 19th- 23th) we had the Annual meeting of the CLIF Consortium Steering Commitee and, two days later, the General Assembly.

In both meetings, a general overview was presented on all the activities done during the previous year, and we also had a special focus on the development of the EF Clif and the enlargement of the CLIF Consortium hospital network (100 hospitals). In addition, we spent some time in presenting new projects and ideas, in both clinical and translational research, to be developed in the short and mid-term.

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April 06th 2017 The inclusion of patients in the PREDICT Study began in March 2017 The recruitment has started in 18 hospitals

6 more centres will join next week

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February 10th 2017 NEWS FROM THE GRIFOLS CHAIR #2 Richard Moreau, Joan Clària, Vicente Arroyo

A lesson drawn from the CANONIC study was that among patients with acutely decompensated cirrhosis, systemic inflammation was much more marked in patients with acute-on-chronic liver failure (ACLF) than in those without. The mechanisms explaining exaggerated systemic inflammation in patients with ACLF are poorly understood.

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February 06th 2017 THE PREDICT STUDY KICK-OFF MEETING HELD IN BARCELONA The meeting took place at the EF Clif Foundation offices in Barcelona on 18th January PIs from the 48 participating centres gathered to discuss the execution of the first step of the project and shared their views and thoughts on the development of the PREDICT Study

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January 14th 2017 PREDICT STUDY. KICK-OFF MEETING The meeting will take place in Barcelona on January 18th at the EF Clif headquarters

48 PIs from all over Europe will gather in Barcelona to review and approve the details of the PREDICT Study, which is expected to start next month This will give us the opportunity to get together all the people involved in the preparation, management and execution of the Study.

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December 12th 2016 THE CELLEX FOUNDATION CONTRIBUTES WITH A DONATION TO THE PREDICT STUDY The Cellex contribution will allow Dr Jonel Trebicka to stay in Barcelona as a Visiting Professor for two years and to lead the new flagship Project of the EF Clif.

Dr Trebicka will be the Principal Investigator of the Predict Study, promoted by the EF Clif, which is meant to be fundamental to uncover mechanistic and pathophysiological processes associated with the development and clinical course of ACLF and to identify the precipitating events of ACLF.

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October 16th 2016 NEWS FROM THE GRIFOLS CHAIR #1 Richard Moreau, Joan Clària, Vicente Arroyo

The Grifols Chair for Translational Research has been recently created because of the results of the CANONIC study showing that acute-on-chronic liver failure (ACLF) was associated with systemic inflammation, assessed with routinely available markers such as white-cell count and plasma C-reactive protein levels (1).

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April 12th 2016 SYSTEMIC INFLAMMATION AND ORGAN FAILURE IN CIRRHOSIS. THE ACUTE-ON-CHRONIC LIVER FAILURE SYNDROME (ACLF) The first international meeting of the EF Clif was held on 12th April 2016 at the Hilton Hotel in Barcelona

Over two hundred specialists from all over the world, mostly European hepatologists, attended the lectures of the symposium. The event just preceded the start of the 51st Annual Congress of the European Association for the Study of the Liver (EASL 2016), which took place in Barcelona between April 13th and 17th.

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