April 12, 2016 SYSTEMIC INFLAMMATION AND ORGAN FAILURE IN CIRRHOSIS. THE ACUTE-ON-CHRONIC LIVER FAILURE SYNDROME (ACLF) The first international meeting of the EF Clif was held on 12th April 2016 at the Hilton Hotel in Barcelona

Over two hundred specialists from all over the world, mostly European hepatologists, attended the lectures of the symposium. The event just preceded the start of the 51st Annual Congress of the European Association for the Study of the Liver (EASL 2016), which took place in Barcelona between April 13th and 17th.

The one day session main focus was on the Acute Liver Failure Chronic-on- Syndrome (ACLF). This syndrome was accurately described, three years ago, in the CANONIC study by a number of investigators associated to the EASL-CLIF Consortium, and has led to a string of ancillary studies covering particular aspects of this syndrome. The findings of these studies have represented a paradigm shift in the study of this syndrome, associated with hepatic cirrhosis, and opens new perspectives in the study of chronic liver diseases.

Dr. Vicente Arroyo, as President of the Board of Trustees of the EF Clif, opened the sessions in which 15 speakers presented different aspects of the syndrome, from different perspectives, illustrated some research advances and anticipated ACLF study lines for the coming years. The novelty of this topic issue has aroused widespread interest in the audience and stimulated their active participation during the whole day.

The symposium was the first major scientific event organized by the Foundation, since its establishment in mid-2015, and has served as a public presentation of its activities and projects to the international scientific community in the field of Hepatology.

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