February 23, 2023 Celebrating 10 years of CANONIC: It's all about improving care and survival for patients with ACLF To celebrate 10 years since the publication of results from the CANONIC study, we talked with Prof. Richard Moreau, leading researcher in this prospective observational investigation, about the impact of chronic liver disease, approaches to treatment, and best practices.

The CANONIC study – European Association for the Study of the Liver (EASL)–Chronic Liver Failure (CLIF) Consortium acute-on-chronic liver failure in cirrhosis – was unprecedented in its scope and findings providing the means for the first evidence-based definition of the syndrome referred to as "acute-on-chronic liver failure" (ACLF). Although no universal definition of ACLF has been yet recognized, the EASL-CLIF Consortium diagnostic criteria has been applied and validated worldwide. Results from the CANONIC study opened up a new venue of liver disease research that will continue expanding in the following years.

Here is what Prof. Moreau had to say. Watch and listed this interview on YouTube.


The CANONIC study, a prospective observational study in 1349 patients with decompensated cirrhosis admitted to 29 European hospitals, aimed to characterize a syndrome that later would be referred to as acute-on-chronic liver failure (ACLF). The CANONIC study has allowed for a comprehensive assessment of the epidemiology, natural history, diagnostic criteria, clinical course, prognosis, prevention and treatment of ACLF.