November 30, 2023 Celebrating 10 years of CANONIC: A paradigm shift in chronic liver disease research To celebrate 10 years since the publication of the results from the CANONIC study, we talked with Prof. Vicente Arroyo, senior author in the paper published in Gastroenterology, to discuss about the past, present and future of chronic liver disease research.

The CANONIC study – European Association for the Study of the Liver (EASL)–Chronic Liver Failure (CLIF) Consortium acute-on-chronic liver failure in cirrhosis – was the first large, prospective study ever conducted aimed at establishing a definition for acute-on-chronic liver failure (ACLF). Prof. Arroyo is internationally renowned for his research liver disease and inflammation.

Here is what Prof. Arroyo had to say. Watch and listed this interview on YouTube.


The CANONIC study, a prospective observational study in 1349 patients with decompensated cirrhosis admitted to 29 European hospitals, aimed to characterize a syndrome that later would be referred to as acute-on-chronic liver failure (ACLF). The CANONIC study has allowed for a comprehensive assessment of the epidemiology, natural history, diagnostic criteria, clinical course, prognosis, prevention and treatment of ACLF.