July 12, 2023 Celebrating 10 years of CANONIC: Enabling better clinical management of patients with ACLF To celebrate the 10th aniversary of the publication of results from the CANONIC study that allowed for the definition of the syndrome we refer to as "acute-on-chronic liver failure" (ACLF), we took the opportunity to catch up with Dr. Minneke Coenraad at the EASL Congress 2023 to discuss her views on the past, present and future of hepatology.

Dr. Minneke Coenraad is Gastroenterologist and Hepatologist at Leiden University Medical Center, The Netherlands. Her research covers a wide breadth of areas including hepatocellular carcinomas, complications of cirrhosis and liver transplantation.

Here is what Dr. Coenraad had to say. Watch and listed this interview on YouTube.


The CANONIC study, a prospective observational study in 1349 patients with decompensated cirrhosis admitted to 29 European hospitals, aimed to characterize a syndrome that later would be referred to as acute-on-chronic liver failure (ACLF). The CANONIC study has allowed for a comprehensive assessment of the epidemiology, natural history, diagnostic criteria, clinical course, prognosis, prevention and treatment of ACLF.